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1. A Nontreponemal assay (traditional algorithm), such as the rapid plasma reagin (RPR) test, is an indicator of an active or recent syphilis infection and can be used to monitor response to therapy over time

Nontreponemal

2. The Nontreponemal testing algorithm is recommended by the CDC, preferred by doctors and used in a majority of labs for syphilis screening.

Nontreponemal

3. Nontreponemal tests (e.g., VDRL and RPR) are simple, inexpensive, and are often used for screening. However, they are not specific for syphilis, can produce false-positive results, and, by themselves, are insufficient for diagnosis

Nontreponemal, Not

4. The role of Nontreponemal antibodies in the Treponema pallidum infection course is unclear

Nontreponemal

5. We investigated the effect of immunization with Nontreponemal antigen on T

Nontreponemal

6. Nontreponemal antigen was injected intravenously into rabbits in the Nontreponemal group (n = …

Nontreponemal

7. Nontreponemal test titers usually decline after treatment and might become nonreactive with time; however, in some persons, Nontreponemal antibodies can persist for a long period of time, a response referred to as the “serofast reaction.”

Nontreponemal, Nonreactive

8. Nontreponemal assays date to 1906, when August Paul von Wassermann in Germany described the first serologic test for syphilis based on complement fixation, later termed the Wassermann test or Wassermann reaction.

Nontreponemal

9. Nontreponemal tests usually become nonreactive with time after treatment

Nontreponemal, Nonreactive

10. In some patients, however, Nontreponemal antibodies can persist at a low titer (a titer less than 1:8 is generally considered “low”) for a long period of time, sometimes for the life of the patient

Nontreponemal

11. The Nontreponemal tests are quite useful for monitoring the patient's response to treatment, because the titers reflect disease activity

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12. The ASI Evolution® is the world’s first and only fully-automated system for Nontreponemal RPR Syphilis testing for diagnostic, blood donor and cadaveric tissue screening

Nontreponemal

13. By comparison, Nontreponemal antibodies typically disappear in an adequately treated person after about 3 years

Nontreponemal

14. Therefore, a positive treponemal screening result must be followed by a Nontreponemal test (such as RPR) to differentiate between an active infection (or reinfection) and one that occurred in the past and was successfully treated.

Nontreponemal

15. Nontreponemal tests may revert to negative following treatment (seroreversion); this is more likely to occur with low initial titers and with treatment in the primary or secondary stage.29 Some

Nontreponemal, Negative

16. The Nontreponemal is a quantitative measure and the treponemal is to confirm, both as part of diagnostic steps

Nontreponemal

17. Serology: Two types of serologic tests are required to diagnosis syphilis, Nontreponemal and treponemal

Nontreponemal

18. Nontreponemal antibody tests--these tests are called "Nontreponemal" because they detect antibodies that are not specifically directed against the Treponema pallidum bacterium

Nontreponemal, Not

19. Screening that begins with a treponemal test identifies persons with positive treponemal and negative Nontreponemal test results who were missed when screening began with a Nontreponemal test

Negative, Nontreponemal

20. 28:317-318, 1974) can be used as a substitute for other Nontreponemal antigens used in screening tests for syphilis.

Nontreponemal

21. Nontreponemal Test Serological Tests for Syphilis (STS) Syphilis Serology Patient Instructions: FAQ: Syphilis

Nontreponemal

22. Nontreponemal antigen test any of various tests detecting serum antibodies to reagin (cardiolipin and lecithin) derived from host tissues in the diagnosis of the Treponema pallidum infection of syphilis .

Nontreponemal

23. The VDRL test is 1 of 3 Nontreponemal tests for detecting syphilis

Nontreponemal

24. Nontreponemal tests are not specific to syphilis and can yield false-positive results

Nontreponemal, Not

25. Algorithms where a Nontreponemal test is followed by a treponemal test, to those where the algorithm is reversed such that a treponemal test is performed first, followed by a Nontreponemal assay

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26. Nontreponemal antibody titers often persist despite an appropriate treatment response

Nontreponemal

27. The ASI RPR Card Test is an 8-minute macroscopic Nontreponemal flocculation test to be used for the detection of reagin

Nontreponemal

28. We also report on reactive Nontreponemal tests in conditions other than syphilis, false negatives, and automated Nontreponemal tests

Nontreponemal, Negatives

29. Nontreponemal tests remain positive after successful treatment.

Nontreponemal

30. Nontreponemal tests detect anticardiolipin antibodies and are not specific to syphilis (3, 4)

Nontreponemal, Not

31. Specimens with a reactive Nontreponemal result and a nonreactive treponemal test result are considered biological false positives (BFPs) and make up 14 to 40% of reactive Nontreponemal tests, depending on the prevalence of syphilis (1, 5).

Nontreponemal, Nonreactive

32.Nontreponemal Assay – microscopic flocculation test – Others include: RPR, TRUST, VDRL • Detects total AB produced against cardiolipin (reagin) Wasserman Test – Cardiolipin released as a result of tissue destruction (chancre) – Nonspecific antibody (not vs T

Nontreponemal, Nonspecific, Not

33. Pallidum) hence Nontreponemal • Reported as titers, used to monitor tx.

Nontreponemal

34. An evaluation of a novel dual treponemal/Nontreponemal point-of-care test for syphilis as a tool to distinguish active from past treated infection

Novel, Nontreponemal

35. The standard Nontreponemal test is the VDRL slide test, in which serum is tested for its ability to flocculate a suspension of cardiolipin-cholesterol-lecithin antigen

Nontreponemal

36. Nontreponemal tests usually become nonreactive with time after treatment

Nontreponemal, Nonreactive

37. In some patients, however, Nontreponemal antibodies can persist at a low titer (the definition “low” titer is dependent on laboratory and clinical context, but less than 1:8 is generally consider “low”) for a long period of time, sometimes for the life of the patient.

Nontreponemal

38. The ASI RPR Card Test is an 8-minute macroscopic Nontreponemal flocculation test to be used for the detection of reagin

Nontreponemal

39. Nontreponemal assays detect the immune response to the release of cardiolipin, cholesterol and lecithin, which are elevated in numerous chronic conditions and infections including syphilis.9 If the Nontreponemal assay is reactive, the serum or plasma specimen is serially diluted two-fold to determine the endpoint titer.

Nontreponemal, Numerous

40. Reactive Nontreponemal and treponemal tests from an individual whose only possible exposure occurred within the preceding 12 months; Syphilis, late latent

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41. Serological tests are divided into two types: Nontreponemal and treponemal

Nontreponemal

42. Working day of the Nontreponemal test result, as required by law

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43. • A quantitative Nontreponemal test and titer should be performed to facilitate future clinical management

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44. • If the EIA/CIA is positive and the Nontreponemal test is negative (discordant results), a reflex …

Nontreponemal, Negative

45. Ugandan national guidelines recommend a Nontreponemal rapid plasma reagin (RPR) followed by treponemal testing for diagnosis of syphilis.

National, Nontreponemal

46. The Nontreponemal assays are semi-quantitative and the amount of antibody present (both IgM and IgG) generally reflects the activity of the infection

Nontreponemal

47. Positive Nontreponemal tests are reported as a titer of antibody (e.g

Nontreponemal

48. The Nontreponemal antibodies are indicators of active infection since a significant reduction in titer can be used to suggest success of therapy, while a significant increase can indicate a possible relapse or reinfection

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49. The Nontreponemal antigen is a mixture of cardiolipin,

Nontreponemal

50. The Nontreponemal antibodies are not specifically directed at the Treponema pallidum bacterium

Nontreponemal, Not

51. In the United States, testing for syphilis traditionally has consisted of initial screening with an inexpensive Nontreponemal test, then retesting reactive specimens with a more specific, and more expensive, treponemal test

Nontreponemal

52. The traditional syphilis screening approach when the first-line test is a Nontreponemal assay (like RPR) and if positive, the second-line confirmatory test is a treponemal test (such as TP-PA) was developed many years ago when treponemal tests lacked necessary sensitivity but delivered acceptable specificity.

Nontreponemal, Necessary

53. Unlike the Nontreponemal tests, once the FTA-ABS test becomes reactive, it will remain reactive for many years

Nontreponemal

54. A quantitative Nontreponemal test should be performed on infant serum and, if reactive, the infant should be examined thoroughly for evidence of congenital syphilis

Nontreponemal

55. Nontreponemal test reactive Treponemal test non-reactive

Nontreponemal, Non

56. Nontreponemal and Treponemal Test both reactive

Nontreponemal

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NONTREPONEMAL

Frequently Asked Questions

What is a nontreponemal test?

A nontreponemal test ( NTT) is a blood test for diagnosis of infection with syphilis. Nontreponemal tests are an indirect method in that they detect biomarkers that are released during cellular damage that occurs from the syphilis spirochete. In contrast, treponemal tests look for antibodies...

What does Treponema mean?

Also found in: Thesaurus, Medical, Wikipedia. Any of a group of spirochetes of the genus Treponema, including those that cause syphilis, pinta, and yaws. [New Latin Treponēma, genus name : Greek trepein, to turn; see trep- in Indo-European roots + Greek nēma, thread; see (s)nē- in Indo-European roots .]

What is a positive treponemal test?

Treponemal tests are qualitative only and are reported as "reactive" or "nonreactive" Once a patient has a positive treponemal test, this test usually remains positive for life. Thus, these tests are generally not useful for confirming a diagnosis of syphilis in a patient with prior treated disease.

When do reactive treponemal tests revert to serological nonreactive?

Most patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regardless of treatment or disease activity. However, 15%–25% of patients treated during the primary stage revert to being serologically nonreactive after 2–3 years ( 397 ).

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