Use Noninferior in a sentence

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See also: Noninferior Non Nonillion Noninvasive Noninfectious Nonischemic Noni Nonionic Nonimmigrant Nonintrusive Noninclusive

1. The researchers found that daily netarsudil was Noninferior to twice-daily timolol, with a mean treated IOP range from 16.3 to 17.9 mm Hg for netarsudil and 16.7 to 17.6 mm Hg for timolol (mean …

Netarsudil, Noninferior

2. In a Noninferiority trial, one is interested in showing that the new treatment is not inferior to the standard treatment

Noninferiority, New, Not

3. THURSDAY, May 6, 2021 (HealthDay News) -- A four-month rifapentine-based regimen containing moxifloxacin is Noninferior to a standard six-month regimen for treatment of tuberculosis, according to a study published in the May 6 issue of the New England Journal of Medicine.

News, Noninferior, New

4. In 2 Japanese trials of nondialysis patients, molidustat proved Noninferior to darbepoetin alfa, an erythropoiesis-stimulating agent, in correcting and maintaining hemoglobin levels over 36 weeks.

Nondialysis, Noninferior

5. The proposed bevacizumab biosimilar BE1040V was found to be Noninferior to its reference product in terms of efficacy for the treatment of metastatic colorectal cancer (mCRC), according to a study


6. The second-generation BTK inhibitor acalabrutinib (Calquence) demonstrated Noninferiority with regard to progression-free survival (PFS) and a …


7. Background and Purpose- TNK (tenecteplase), a newer fibrinolytic agent, has practical delivery advantages over ALT (alteplase) that would make it a useful agent if Noninferior in acute ischemic stroke treatment outcome

Newer, Noninferior

8. Nichole Tucker The use of zanubrutinib was found to be Noninferior to treatment with ibrutinib for adult patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma, meeting the primary end point of the phase 3 ALPINE trial.

Nichole, Noninferior

9. Daprodustat is Noninferior to the erythropoiesis-stimulating agent (ESA) darbepoetin in maintaining target-range hemoglobin (Hb) levels in patients receiving hemodialysis (HD), a …


10. Antibiotic treatment was Noninferior to appendectomy for appendicitis, according to the results of a pragmatic, nonblinded, Noninferiority, randomized trial published in …

Noninferior, Nonblinded, Noninferiority

11. A Noninferior solution is one in which an improvement in one objective requires a degradation of another


12. In the current phase III trial, Xu and colleagues tested whether this modified XELIRI regimen was Noninferior to FOLFIRI with or without bevacizumab as second-line treatment


13. 2 days ago · THURSDAY, May 6, 2021 (HealthDay News) — A four-month rifapentine-based regimen containing moxifloxacin is Noninferior to a standard six-month regimen for treatment of tuberculosis, according to a study published in the May 6 issue of the New England Journal of Medicine.

Nbsp, News, Noninferior, New

14. The following examples illustrate designing Noninferiority studies and conducting Noninferiority tests


15. Further in-depth discussion of Noninferiority and equivalence testing, and several examples, can be found in Castelloe and Watts (2015).


16. Example 1: Noninferiority test for a proportion


17. (HealthDay)—Linagliptin is Noninferior to glimepiride for adults with relatively early type 2 diabetes and elevated cardiovascular risk, according to a study published online Sept


18. Antibiotic Treatment Is Noninferior to Appendectomy for Acute Appendicitis


19. According to the results of the randomized phase III AXEPT clinical trial, a chemotherapy doublet has proved Noninferior to treatment with standard FOLFIRI (folinic acid [leucovorin], fluorouracil [5-FU], and irinotecan) for patients with previously treated metastatic colorectal cancer (mCRC)


20. (HealthDay)—For patients with HIV-1 suppression, long-acting cabotegravir plus rilpivirine is Noninferior to oral therapy with dolutegravir-abacavir-lamivudine and standard oral therapy


21. If subsequent studies have similarly Noninferior results, Huafeng Wang, MD, coauthor of the study, speculated that following these promising findings, there is a possibility for administering


22. Rivaroxaban is Noninferior to warfarin regarding the mean time until death, major cardiovascular events, or major bleeding at 12 months among patients with atrial fibrillation (AF) and a bioprosthetic mitral valve, according to study results in the New England Journal of Medicine.

Noninferior, New

23. Subcutaneous Daratumumab is Noninferior to IV Administration in Relapsed/Refractory Myeloma Wednesday, July 1, 2020 Subcutaneous daratumumab was found to be Noninferior to intravenous (IV) daratumumab in patients with relapsed or refractory multiple myeloma (MM), according to results from the phase III COLUMBA trial.


24. •If A is Noninferior to B and B is Noninferior to C, then it does NOT necessarily follow that A is Noninferior to C –Could be a problem with iterative generations of predicate devices •Consider selecting the best available control Is a NI trial appropriate? 14 MRSA: The Superbug

Noninferior, Not, Necessarily, Ni

25. Ertugliflozin Noninferior for CV Outcomes in T2DM With ASCVD


26. 15, 2020 -- Ertugliflozin is Noninferior to placebo with respect to major adverse cardiovascular events among patients with type 2 diabetes and atherosclerotic cardiovascular disease, according to a study published online Oct


27. Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin is not Noninferior to a combination of IV and oral …

Not, Noninferior

28. Wang told the conference that while the intramuscular injection was inferior to intra-articular injections at 4 weeks, it was Noninferior at 8 and 24 weeks and should be considered an effective way to reduce pain in patients with knee OA.


29. The combination of carboplatin plus pemetrexed with pemetrexed maintenance was Noninferior to docetaxel, with prolonged survival and an improved safety profile, among elderly patients with


30. In patients with cancer-associated venous thromboembolism (VTE), treatment with oral apixaban was Noninferior to subcutaneous dalteparin for the prevention of recurrent VTE, according to findings from the phase III CARAVAGGIO trial.


31. That result meant that a DTG regimen was virologically Noninferior to a DRV/r regimen after 48 weeks of second-line therapy


32. Nab-paclitaxel (Abraxane) proved to be Noninferior to docetaxel, having showcased improved progression-free survival (PFS), overall survival …

Nab, Noninferior

33. Question Among patients with ischemic stroke secondary to large vessel occlusion and eligible for thrombolysis, is endovascular treatment alone Noninferior to intravenous alteplase plus endovascular treatment with regard to functional independence?


34. The objectives of this study are: 1) to determine if participant comprehension of research informed consent is Noninferior using telemedicine‐based compared with standard face‐to‐face (F2F) consent in ED clinical trials, 2) to compare study accrual rates of telemedicine‐based and standard research informed consent, and 3) to elicit


35. Ceftaroline 600 mg every 8 hours, via 2 hour intravenous infusion, has demonstrated tolerability in individuals with complicated skin and soft tissue infection, according to a study published in the Journal of Antimicrobial Chemotherapy.It achieved Noninferiority compared with the 12-hour regimen in terms of tolerability and safety.


36. In conclusion, accumulated clinical trial data indicates intravenous TNK is Noninferior to ALT in the treatment of AIS


37. Every 4 weeks (Q4W) was Noninferior to daily oral 3-drug ART in Phase 3 studies


38. Second, remember that Noninferior is not the same as equivalent or superior

Noninferior, Not

39. Monthly injections of long-acting formulations of cabotegravir and rilpivirine were Noninferior to daily oral combination antiretroviral therapy (CAR) for maintaining HIV-1 suppression and also offered improved treatment satisfaction, according to research presented at the 10th IAS Conference on HIV Science, held July 21 to 24, in Mexico City, Mexico.


40. “A strategy based on platelet reactivity-guided is Noninferior to the standard of care in patients with acute coronary syndromes awaiting CABG regarding peri-operative bleeding, significantly shortens the waiting time to CABG, and decreases hospital expenses,” the authors wrote in the study.


41. SWITCHING TO DTG/3TC FDC IS Noninferior TO TBR FOR 96 WEEKS: TANGO SUBGROUP ANALYSES CROI 2021 March 6 Reported by Jules Levin Paul Benson1, Clifford A


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Frequently Asked Questions

What is the noninferiority margin?

The non-inferiority margin is the maximum difference between the treatments for which the outcomes can be considered to be “equal”. In the current example, a difference of one month, say, might be the maximum that can be considered equal, so the non-inferiority margin would be one month.

What is a non inferior clinical trial?

Non-inferior clinical trial: A clinical trial that shows that a new treatment is equivalent to standard treatment. Also called a non-inferiority trial. See: Clinical trials.

What is the life expectancy of a non-inferior?

For new treatment: 12.0 months. Estimate of the difference in survival times: 12.0 – 12.1 = -0.1 months. 95% confidence interval (CI) for the difference: -0.3 to 0.1 months. Even though we may assume that this difference is small enough to conclude non-inferiority, this is where the non-inferiority margin comes in.

Is progression-free survival noninferior?

N Engl J Med 2013;369:722-31), progression-free survival was shown to be noninferior if the upper bound of the 95% CI for the adjusted estimated HR was less than 1.25 (non-inferiority margin).

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