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See also: Clathrin Clatter Clattering Clat Clattered Clathrate Clutch Collate Clattery Clattanoia Culture

1. Clathrin-mediated endocytosis (CME) is an extremely important endocytic mechanism

Clathrin, Cme

2. β 2 AR, like many other GPCRs, undergo rapid endocytosis through Clathrin-coated pits (CCPs), and subsequently form Clathrin-coated vesicles (CCVs)

Clathrin, Coated, Ccps, Ccvs

3. Clathrin a protein of eukaryotic cells occurring in indentations of the plasma membrane

Clathrin, Cells

4. These indentations are known as Clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.

Clathrin, Coated

5. Clathrin cages are composed of symmetrical three-legged components called triskelions

Clathrin, Cages, Composed, Components, Called

6. Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the Clathrin-coated pits of classical endocytosis

Clathrin, Cargo, Cage, Coated, Classical

7. This review describes the structures of Clathrin, major cargo adaptors, and other proteins that participate in forming a Clathrin-coated pit, loading its

Clathrin, Cargo, Coated

8. Definition of Clathrin in the Definitions.net dictionary

Clathrin

9. What does Clathrin mean? Information and translations of Clathrin in the most comprehensive dictionary definitions

Clathrin, Comprehensive

10. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Clathrin, Coat, Coated

11. Two different adapter protein complexes link the Clathrin lattice either to the plasma membrane or to the trans-Golgi network

Complexes, Clathrin

12. Acts as component of the TACC3/ch-TOG/Clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge …

Component, Ch, Clathrin, Complex, Contribute

13. CLTC (Clathrin Heavy Chain) is a Protein Coding gene

Cltc, Clathrin, Chain, Coding

14. The Clathrin on the pits acts as a sensor for signals that activate endocytosis while the vesicle from the Clathrin Coated vesicles gets recycled to the cell membrane

Clathrin, Coated, Cell

15. The cycle between the Clathrin-coated pits and Clathrin-coated vesicles formation is continuous as long as there are signaling receptors and ligands that activate them.

Cycle, Clathrin, Coated, Continuous

16. Clathrin definition, a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis

Clathrin, Cell, Coated

17. The growing Clathrin coat scaffolds the curvature, and since Clathrin triskelia posess an intrinsic pucker angle, they polymerize to form a curved basketlike structure

Clathrin, Coat, Curvature, Curved

18. Since individual Clathrin heavy chains interactions are on the order of thermal fluctuations, Clathrin is thought to play a more curvature stabilizing role in endocytosis.

Clathrin, Chains, Curvature

19. Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes

Clathrin, Cell, Cargoes

20. Medical definition of Clathrin: the major component protein of a cagelike polyhedral molecular arrangement that forms on the cytoplasmic side of a cell's plasma membrane and coats the endocytotic vesicles which bud off from the membrane.

Clathrin, Component, Cagelike, Cytoplasmic, Cell, Coats

21. Receptor-mediated endocytosis (RME), also called Clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).This process forms vesicles containing the absorbed substances and is strictly mediated by receptors on the surface of the cell.

Called, Clathrin, Cells, Cases, Containing, Cell

22. Clathrin-mediated endocytosis (CME) is a vesicular transport event that facilitates the internalization and recycling of receptors engaged in a variety of processes, including signal transduction (G-protein and tyrosine kinase receptors), nutrient uptake and synaptic vesicle reformation

Clathrin, Cme

23. Clathrin was discovered nearly 25 years ago

Clathrin

24. Since then, a large number of other proteins that participate in the process by which Clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified

Clathrin, Coated

25. Clathrin mediated endocytosis (CME) is the key cellular progress of internalising a cargo, either on the plasma membrane (PM) or outside the cell, into the cell

Clathrin, Cme, Cellular, Cargo, Cell

26. The cargos are packaged inside a small vesicle, which is covered by a coat made of the protein Clathrin.

Cargos, Covered, Coat, Clathrin

27. A Clathrin-coated bud or vesicle in the Golgi region (G) is indicated with the arrow in f

Clathrin, Coated

28. (g) Clathrin-depleted cells have no recognizable Clathrin-coated pits or vesicles, either at the plasma membrane or on intracellular membranes, although COP-coated vesicles can still …

Clathrin, Cells, Coated, Cop, Can

29. Depletion of Clathrin and dynamin enhances expression of LTβR target genes in A549 cells

Clathrin, Cells

30. MRNA levels of NF-κB target genes were analyzed by qRT-PCR in A549 cells transfected with siRNAs targeting Clathrin (CHC, two oligonucleotides denoted with consecutive numbers) (a, b), dynamin-1/2 (three combinations of oligonucleotides targeting dynamin

Cells, Clathrin, Chc, Consecutive, Combinations

31. Clathrin-dependent endocytosis is an essential cellular process shared by all cell types

Clathrin, Cellular, Cell

32. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles

Clathrin, Coat, Coated

33. Acts as component of the TACC3/ch-TOG/Clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).

Component, Ch, Clathrin, Complex, Contribute

34. This study reveals that diversity of Clathrin light chain (CLC) subunits alters Clathrin properties and demonstrates that the two neuronal CLC subunits work together for optimal Clathrin function in synaptic vesicle formation

Clathrin, Chain, Clc

35. Our findings establish a role for CLC diversity in synaptic transmission and illustrate how CLC variability expands the complexity of Clathrin to serve tissue …

Clc, Complexity, Clathrin

36. Clathrin plays a major role in the formation of coated vesicles 8,9.Clathrin-coated vesicles sort cargos from different membrane compartments, including the …

Clathrin, Coated, Cargos, Compartments

37. Clathrin-coated pits: vive la différence? Benmerah A(1), Lamaze C

Clathrin, Coated

38. Through bivalent interactions with Clathrin and/or other CLASP proteins, they bridge the recruitment of the cargo to the emerging Clathrin coated pit (reviewed in Traub and Bonifacino, 2013)

Clathrin, Clasp, Cargo, Coated

39. The tetrameric AP-2 complex, first identified in early studies of Clathrin-mediated endocytosis, was at one time thought to be the primary CLASP protein

Complex, Clathrin, Clasp

40. Although endocytosis in yeast is defined as a Clathrin-mediated process, Clathrin itself is dispensable for endocytosis in yeast (Payne 1990; Munn et al

Clathrin

41. 1993), and subsequent studies have shown that although Clathrin facilitates endocytic site assembly, it is not required for membrane invagination or vesicle formation.

Clathrin

42. Clathrin-mediated endocytosis This animation shows the process of Clathrin-mediated endocytosis of transferrin receptors, focusing on the assembly and disass

Clathrin

43. Clathrin is the main constituent of the polygonal network that forms the layer of coated vesicles and coated pits

Clathrin, Constituent, Coated

44. We assessed the role of Clathrin-mediated and caveolae-mediated endocytosis of …

Clathrin, Caveolae

45. Instead, entry occurred via the Clathrin‐mediated endocytosis pathway

Clathrin

46. HBV internalisation was inhibited by pitstop‐2 treatment and RNA‐mediated silencing (siRNA) of the Clathrin heavy chain, adaptor protein AP‐2 and dynamin‐2

Clathrin, Chain

47. We were able to visualise HBV entry in Clathrin‐coated pits and vesicles by electron microscopy (EM) and

Clathrin, Coated

48. Clathrin a protein of eukaryotic cells occurring in indentations of the plasma membrane

Clathrin, Cells

49. These indentations are known as Clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.

Clathrin, Coated

50. The Clathrin heavy chain is known to provide the backbone for the Clathrin lattice

Clathrin, Chain

51. Clathrin light chains contain regulatory domains that influence the recruitment, assembly, and disassembly of Clathrin within the cell.

Clathrin, Chains, Contain, Cell

52. There is good evidence that, in addition to the canonical Clathrin-associated endocytic machinery, mammalian cells possess multiple sets of proteins that are capable of mediating the formation of endocytic vesicles

Canonical, Clathrin, Cells, Capable

53. The identity, mechanistic properties and function of these Clathrin-independent endocytic pathways are currently under investigation

Clathrin, Currently

54. CHC22 Clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans

Clathrin

55. Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis

Clathrin, Component, Covering, Cytoplasmic, Coated

56. Clathrin is a large, soluble protein composed of heavy chains, which have molecular masses of about 192 kD, and light chains

Clathrin, Composed, Chains

57. Goat anti Human Clathrin light chain A/B antibody recognizes the Clathrin light chain A and B Clathrin is a large, soluble protein composed of heavy and light chains

Clathrin, Chain, Composed, Chains

58. Clathrin was discovered nearly 25 years ago

Clathrin

59. Since then, a large number of other proteins that participate in the process by which Clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified

Clathrin, Coated

60. High-resolution structures of parts of Clathrin, …

Clathrin

61. Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level

Clathrin, Cme, Conserved

62. Clathrin HC Antibody (TD.1) is available as both the non-conjugated anti-Clathrin HC antibody form, as well as multiple conjugated forms of anti-Clathrin HC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor ® conjugates

Clathrin, Conjugated, Conjugates

63. Clathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and

Clathrin, Cytosolic, Coat

64. Clathrin-mediated endocytosis (CME) is crucial for modulating the protein composition of a cell’s plasma membrane

Clathrin, Cme, Crucial, Composition, Cell

65. Clathrin forms a cage-like, polyhedral outer scaffold around a vesicle, to which cargo-selecting Clathrin adaptors are attached

Clathrin, Cage, Cargo

66. Clathrin-mediated endocytosis is involved in turnover of plasma membrane proteins, uptake of low-density lipoproteins, and endocytosis of several growth factors

Clathrin

67. Clathrin-mediated endocytosis is the main portal of entry into the cell for many soluble and membrane molecules

Clathrin, Cell

68. Clathrin-coated vesicles are formed from the plasma membrane in a sequence of coordinated protein-lipid and protein-protein interactions, starting with adaptor-mediated recruitment of Clathrin to the membrane, proceeding to Clathrin polymerization and assembly into …

Clathrin, Coated, Coordinated

69. "Clathrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Clathrin, Controlled

70. Clathrin-mediated endocytosis—the process by which cells take up nutrients and signals within Clathrin-coated vesicles—is very well understood

Clathrin, Cells, Coated

71. The proteins AP2 and Clathrin are the major constituents of endocytic Clathrin-coated vesicles

Clathrin, Constituents, Coated

72. AP2 and Clathrin stick together through a Clathrin-binding motif in AP2.

Clathrin

73. Eps15 is a component of Clathrin-coated pits where it interacts with adaptor protein (AP)-2, the major Clathrin adaptor complex, and overexpression of dnEps15 mutants has been shown to inhibit Clathrin-dependent endocytosis

Component, Clathrin, Coated, Complex

74. Transferrin, a bona fide cargo of Clathrin

Cargo, Clathrin

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Dictionary

CLATHRIN

Frequently Asked Questions

What does clathrin mean?

Clathrin definition, a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis. See more.

What is the shape of clathrin?

Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1975. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they form a polyhedral lattice that surrounds the vesicle.

What is clathrin dependent endocytosis?

Clathrin-dependent endocytosis allows cells to internalize receptors, ion channels, and extracellular molecules, bringing them into the cell within a protein-coated vesicle. This process involves the formation of special membrane patches called pits, which are defined by the presence of the cytosolic protein clathrin.

What is the function of clathrin in non dividing cells?

Clathrin has another function aside from the coating of organelles. In non-dividing cells, the formation of clathrin-coated vesicles occurs continuously. Formation of clathrin-coated vesicles is shut down in cells undergoing mitosis.

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