1. Clathrin-mediated endocytosis (CME) is an extremely important endocytic mechanism
2. β 2 AR, like many other GPCRs, undergo rapid endocytosis through Clathrin-coated pits (CCPs), and subsequently form Clathrin-coated vesicles (CCVs)
Clathrin, Coated, Ccps, Ccvs
3. Clathrin a protein of eukaryotic cells occurring in indentations of the plasma membrane
4. These indentations are known as Clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.
5. Clathrin cages are composed of symmetrical three-legged components called triskelions
Clathrin, Cages, Composed, Components, Called
6. Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the Clathrin-coated pits of classical endocytosis
Clathrin, Cargo, Cage, Coated, Classical
7. This review describes the structures of Clathrin, major cargo adaptors, and other proteins that participate in forming a Clathrin-coated pit, loading its
Clathrin, Cargo, Coated
8. Definition of Clathrin in the Definitions.net dictionary
9. What does Clathrin mean? Information and translations of Clathrin in the most comprehensive dictionary definitions …
10. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles
Clathrin, Coat, Coated
11. Two different adapter protein complexes link the Clathrin lattice either to the plasma membrane or to the trans-Golgi network
12. Acts as component of the TACC3/ch-TOG/Clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge …
Component, Ch, Clathrin, Complex, Contribute
13. CLTC (Clathrin Heavy Chain) is a Protein Coding gene
Cltc, Clathrin, Chain, Coding
14. The Clathrin on the pits acts as a sensor for signals that activate endocytosis while the vesicle from the Clathrin Coated vesicles gets recycled to the cell membrane
Clathrin, Coated, Cell
15. The cycle between the Clathrin-coated pits and Clathrin-coated vesicles formation is continuous as long as there are signaling receptors and ligands that activate them.
Cycle, Clathrin, Coated, Continuous
16. Clathrin definition, a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis
Clathrin, Cell, Coated
17. The growing Clathrin coat scaffolds the curvature, and since Clathrin triskelia posess an intrinsic pucker angle, they polymerize to form a curved basketlike structure
Clathrin, Coat, Curvature, Curved
18. Since individual Clathrin heavy chains interactions are on the order of thermal fluctuations, Clathrin is thought to play a more curvature stabilizing role in endocytosis.
Clathrin, Chains, Curvature
19. Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes
Clathrin, Cell, Cargoes
20. Medical definition of Clathrin: the major component protein of a cagelike polyhedral molecular arrangement that forms on the cytoplasmic side of a cell's plasma membrane and coats the endocytotic vesicles which bud off from the membrane.
Clathrin, Component, Cagelike, Cytoplasmic, Cell, Coats
21. Receptor-mediated endocytosis (RME), also called Clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).This process forms vesicles containing the absorbed substances and is strictly mediated by receptors on the surface of the cell.
Called, Clathrin, Cells, Cases, Containing, Cell
22. Clathrin-mediated endocytosis (CME) is a vesicular transport event that facilitates the internalization and recycling of receptors engaged in a variety of processes, including signal transduction (G-protein and tyrosine kinase receptors), nutrient uptake and synaptic vesicle reformation
23. Clathrin was discovered nearly 25 years ago
24. Since then, a large number of other proteins that participate in the process by which Clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified
25. Clathrin mediated endocytosis (CME) is the key cellular progress of internalising a cargo, either on the plasma membrane (PM) or outside the cell, into the cell
Clathrin, Cme, Cellular, Cargo, Cell
26. The cargos are packaged inside a small vesicle, which is covered by a coat made of the protein Clathrin.
Cargos, Covered, Coat, Clathrin
27. A Clathrin-coated bud or vesicle in the Golgi region (G) is indicated with the arrow in f
28. (g) Clathrin-depleted cells have no recognizable Clathrin-coated pits or vesicles, either at the plasma membrane or on intracellular membranes, although COP-coated vesicles can still …
Clathrin, Cells, Coated, Cop, Can
29. Depletion of Clathrin and dynamin enhances expression of LTβR target genes in A549 cells
30. MRNA levels of NF-κB target genes were analyzed by qRT-PCR in A549 cells transfected with siRNAs targeting Clathrin (CHC, two oligonucleotides denoted with consecutive numbers) (a, b), dynamin-1/2 (three combinations of oligonucleotides targeting dynamin
Cells, Clathrin, Chc, Consecutive, Combinations
31. Clathrin-dependent endocytosis is an essential cellular process shared by all cell types
Clathrin, Cellular, Cell
32. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles
Clathrin, Coat, Coated
33. Acts as component of the TACC3/ch-TOG/Clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Component, Ch, Clathrin, Complex, Contribute
34. This study reveals that diversity of Clathrin light chain (CLC) subunits alters Clathrin properties and demonstrates that the two neuronal CLC subunits work together for optimal Clathrin function in synaptic vesicle formation
Clathrin, Chain, Clc
35. Our findings establish a role for CLC diversity in synaptic transmission and illustrate how CLC variability expands the complexity of Clathrin to serve tissue …
Clc, Complexity, Clathrin
36. Clathrin plays a major role in the formation of coated vesicles 8,9.Clathrin-coated vesicles sort cargos from different membrane compartments, including the …
Clathrin, Coated, Cargos, Compartments
37. Clathrin-coated pits: vive la différence? Benmerah A(1), Lamaze C
38. Through bivalent interactions with Clathrin and/or other CLASP proteins, they bridge the recruitment of the cargo to the emerging Clathrin coated pit (reviewed in Traub and Bonifacino, 2013)
Clathrin, Clasp, Cargo, Coated
39. The tetrameric AP-2 complex, first identified in early studies of Clathrin-mediated endocytosis, was at one time thought to be the primary CLASP protein
Complex, Clathrin, Clasp
40. Although endocytosis in yeast is defined as a Clathrin-mediated process, Clathrin itself is dispensable for endocytosis in yeast (Payne 1990; Munn et al
41. 1993), and subsequent studies have shown that although Clathrin facilitates endocytic site assembly, it is not required for membrane invagination or vesicle formation.
42. Clathrin-mediated endocytosis This animation shows the process of Clathrin-mediated endocytosis of transferrin receptors, focusing on the assembly and disass
43. Clathrin is the main constituent of the polygonal network that forms the layer of coated vesicles and coated pits
Clathrin, Constituent, Coated
44. We assessed the role of Clathrin-mediated and caveolae-mediated endocytosis of …
45. Instead, entry occurred via the Clathrin‐mediated endocytosis pathway
46. HBV internalisation was inhibited by pitstop‐2 treatment and RNA‐mediated silencing (siRNA) of the Clathrin heavy chain, adaptor protein AP‐2 and dynamin‐2
47. We were able to visualise HBV entry in Clathrin‐coated pits and vesicles by electron microscopy (EM) and
48. Clathrin a protein of eukaryotic cells occurring in indentations of the plasma membrane
49. These indentations are known as Clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.
50. The Clathrin heavy chain is known to provide the backbone for the Clathrin lattice
51. Clathrin light chains contain regulatory domains that influence the recruitment, assembly, and disassembly of Clathrin within the cell.
Clathrin, Chains, Contain, Cell
52. There is good evidence that, in addition to the canonical Clathrin-associated endocytic machinery, mammalian cells possess multiple sets of proteins that are capable of mediating the formation of endocytic vesicles
Canonical, Clathrin, Cells, Capable
53. The identity, mechanistic properties and function of these Clathrin-independent endocytic pathways are currently under investigation
54. CHC22 Clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans
55. Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis
Clathrin, Component, Covering, Cytoplasmic, Coated
56. Clathrin is a large, soluble protein composed of heavy chains, which have molecular masses of about 192 kD, and light chains
Clathrin, Composed, Chains
57. Goat anti Human Clathrin light chain A/B antibody recognizes the Clathrin light chain A and B Clathrin is a large, soluble protein composed of heavy and light chains
Clathrin, Chain, Composed, Chains
58. Clathrin was discovered nearly 25 years ago
59. Since then, a large number of other proteins that participate in the process by which Clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified
60. High-resolution structures of parts of Clathrin, …
61. Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level
Clathrin, Cme, Conserved
62. Clathrin HC Antibody (TD.1) is available as both the non-conjugated anti-Clathrin HC antibody form, as well as multiple conjugated forms of anti-Clathrin HC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor ® conjugates
Clathrin, Conjugated, Conjugates
63. Clathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and
Clathrin, Cytosolic, Coat
64. Clathrin-mediated endocytosis (CME) is crucial for modulating the protein composition of a cell’s plasma membrane
Clathrin, Cme, Crucial, Composition, Cell
65. Clathrin forms a cage-like, polyhedral outer scaffold around a vesicle, to which cargo-selecting Clathrin adaptors are attached
Clathrin, Cage, Cargo
66. Clathrin-mediated endocytosis is involved in turnover of plasma membrane proteins, uptake of low-density lipoproteins, and endocytosis of several growth factors
67. Clathrin-mediated endocytosis is the main portal of entry into the cell for many soluble and membrane molecules
68. Clathrin-coated vesicles are formed from the plasma membrane in a sequence of coordinated protein-lipid and protein-protein interactions, starting with adaptor-mediated recruitment of Clathrin to the membrane, proceeding to Clathrin polymerization and assembly into …
Clathrin, Coated, Coordinated
69. "Clathrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
70. Clathrin-mediated endocytosis—the process by which cells take up nutrients and signals within Clathrin-coated vesicles—is very well understood
Clathrin, Cells, Coated
71. The proteins AP2 and Clathrin are the major constituents of endocytic Clathrin-coated vesicles
Clathrin, Constituents, Coated
72. AP2 and Clathrin stick together through a Clathrin-binding motif in AP2.
73. Eps15 is a component of Clathrin-coated pits where it interacts with adaptor protein (AP)-2, the major Clathrin adaptor complex, and overexpression of dnEps15 mutants has been shown to inhibit Clathrin-dependent endocytosis
Component, Clathrin, Coated, Complex
74. Transferrin, a bona fide cargo of Clathrin …
Clathrin definition, a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis. See more.
Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1975. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they form a polyhedral lattice that surrounds the vesicle.
Clathrin-dependent endocytosis allows cells to internalize receptors, ion channels, and extracellular molecules, bringing them into the cell within a protein-coated vesicle. This process involves the formation of special membrane patches called pits, which are defined by the presence of the cytosolic protein clathrin.
Clathrin has another function aside from the coating of organelles. In non-dividing cells, the formation of clathrin-coated vesicles occurs continuously. Formation of clathrin-coated vesicles is shut down in cells undergoing mitosis.