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1. Printed in Great Britain PII: S0040-4039(97)00591-1 0040-4039/97 $17.00 + 0.00 New 13-aza Baccatins Maria Menichincheri,* Emanuele Arlandini, Walter Ceccarelli, Maristella Colombo, Luigi Franzoi, Domenico Fusar-Bassini, Nicola Mongelli, Vittorio Pineiroli, Ermes Vanotti Research Laboratories, Pharmacia & Upjohn, viale Pasteur 10, 20014 Nerviano

Britain, Baccatins, Bassini

2. Paclitaxel, along with several key precursors (the Baccatins), occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analogs, such as docetaxel) (Cragg and Newman, 2004), has provided a

Baccatins

3. (4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected Baccatins 9a,b

Boc, By, Baccatins

4. Several key precursors (the Baccatins), occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analogs, such as docetaxel (Taxotere®), has provided a major, renewable natural source of …

Baccatins

5. Paclitaxel, along with several key precursors (the Baccatins), occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analogs, such as docetaxel (Taxotere®), has provided a …

Baccatins

6. Lin S, Geng X, Qu C et al (2000) Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic β-lactams with Baccatins

Baccatins

7. A major renewable natural source was made available to this important class of drugs through the semi-synthetic conversion of Baccatins to paclitaxel, and biologically active paclitaxel related analogs, such as docetaxel

Baccatins, Biologically

8. Together with other Baccatins, the natural product taxol is isolated at low level from needles, seeds, and bark of T

Baccatins, Bark

9. The 2,10-modified Baccatins 5 were synthesized starting from commercially available natural product, 10-deacetylbaccatin III (10-DAB), following the procedures previously reported by us with some modifications [ 20 ].

Baccatins, By

10. Method for separating and purifying 10-deacetyl Baccatins III (PAT - CN101045718) ZHU DEQUAN ZHANG

Baccatins

11. Paclitaxel biosynthesize and occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analogs, such as docetaxel (Taxotere), has provided a major, renewable natural source of this important class of drugs

Biosynthesize, Baccatins

12. Precursors (the Baccatins), occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analog, such as docetaxel (Taxotere®), has provided a major, renewable

Baccatins

13. A series of the second-generation taxoids 21 and 22 with C-3′-CF 2 H- and C-3′-CF 3 - groups, respectively, were synthesized from β-lactams 17 (Rf = CF 2 H or CF 3) and Baccatins 18 by means of the β-Lactam Synthon Method, 35 as shown in Scheme 6

Baccatins, By

14. We show preliminary data on an alternative in vitro biosynthetic method to convert the Baccatins to paclitaxel

Biosynthetic, Baccatins

15. Basically, the nucleus of the paclitaxel molecule (compounds called Baccatins) occurs about three times as often in the leaves or needles of the European yew and other yew species as does the whole molecule.

Basically, Baccatins

16. Precursors (the Baccatins), occurs in the leaves of various Taxus species, and the ready semi-synthetic conversion of the relatively abundant Baccatins to paclitaxel, as well as active paclitaxel analogs, such as docetaxel (Taxotere®), has provided a major, renewable natural source of this important class of drugs

Baccatins

17. 151 The ring-opening coupling reaction of β-lactam (+)-47 with Baccatins 43 (X = H, MeO, N 3 ) and the subsequent removal of the silyl protecting groups gave the corresponding 3

Baccatins

18. Paclitaxel, along with several key precursors (the Baccatins), occurs in the leaves of var- ious Taxus species, and the ready semisynthetic conversion of the relatively abundant Baccatins to pa- clitaxel, and active paclitaxel analogs, such as docetaxel [17], has provided a major, renewable natural

Baccatins

19. The base induced deprotonation of H-14 of 7-triethylsilyl- (7-TES-) and 7-tert-butoxycarbonyl- (7-BOC-) protected 13-oxo-Baccatins gave the corresponding enolates, which were selectively aminated with electrophilic nitrogen donors, such as azodicarboxylates and tosyl azide.

Base, Butoxycarbonyl, Boc, Baccatins

20. Synthesis of highly potent second‐generation taxoids through effective kinetic resolution coupling of racemic β‐lactams with Baccatins Songnian Lin Xudong Geng

Baccatins

21. The base induced deprotonation of H-14 of 7-triethylsilyl- (7-TES-) and 7-tert-butoxycarbonyl- (7-BOC-) protected 13-oxo-Baccatins gave the corresponding enolates, which were selectively aminated with electrophilic nitrogen donors, such as azodicarboxylates and tosyl azide.

Base, Butoxycarbonyl, Boc, Baccatins

22. • Discovery and kilo piloting of lanthanide catalysts for regioselective acylations of Baccatins

Baccatins

23. Baccatins the aromatic ring at the C-2 position

Baccatins

24. And the taxanes, paclitaxel and the Baccatins, shows that they possess a diterpenoid moiety with many features in common, but their biological effects derive primarily from the substituents ‘‘decorating’’ this core

Baccatins, But, Biological

25. Synthesis of novel 3′‐trifluoromethyl taxoids through effective kinetic resolution of racemic 4‐CF 3 ‐β‐lactams with Baccatins Iwao Ojima; John C

Baccatins

26. This strategy allows for the synthesis of Baccatins I (R = H, acetyl) starting from taxane precursor II [R1 = Si(CHMe2)3], which is available starting from (+)-verbenone

Baccatins

27. Baccatins, one of the several key precursors of paclitaxel occurs in the leaves of various Taxus species

Baccatins

28. Its native and semi-synthetic form of Baccatins along with docetaxel (Taxotere®), paclitaxel analogs, stands as a major class of anticancer drugs

Baccatins

29. (Baccatins) which could be converted semi-synthetically into the drug or other active analogs

Baccatins, Be

30. Topics: 10-DAB III, 13-Oxo-Baccatins, 14β-Amino taxanes, Electrophilic amination, Silyl enol ethers, Settore CHIM/06 - Chimica Organica Publisher: Pergamon Elsevier Science Year: 2005

Baccatins

31. Species, and the semisynthetic conversion of Baccatins to paclitaxel, its analogs, has provided a major source of this class of drugs [40]

Baccatins

32. Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with Baccatins

Beta, Baccatins

33. Syntheses of 3'-CF3-taxoids 7 through the coupling of [~-lactams 5 with Baccatins 6

Baccatins

34. Synthesis of modified Baccatins via an oxidation-reduction protocol Tetrahedron Letters

Baccatins

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